Womb cancer ‘highest level in decades’

The number of cases of womb cancer in the UK has reached a 30-year high.

This is according to a study conducted by Cancer Research UK, which revealed that more than 7,530 people develop the disease every year.

Jessica Harris, a health information officer for the group, said: “The risk factors for womb cancer that we know about at the moment are mostly about the levels of different hormones in your body and the balance of the different hormones.”

She added: “When levels of oestrogen in your body are higher and progesterone is lower, it still lets the cells in the womb grow, and that happening over a long period of time can lead to an increase of womb cancer.”

Hormonal changes in overweight or obese women could be responsible for the high number of cases, as could a drop in the number of pregnancies, experts at the charity suggested.

Tour de France 2010: Protocol observed for Alberto Contador’s coronation

Tour de France 2010

A handful of kilometres into today’s final stage of the 2010 Tour de France, Alberto Contador was handed the traditional flûte of champagne and shared a toast with his fellow members of the Astana team as they rolled out of Longjumeau towards Paris. This, surely, would have been the moment for Andy Schleck to attack.

Only 39 seconds separated Schleck from the man in the yellow jersey after 3,500km and 19 days of racing. There would have been long odds against the chance of the Luxembourgeois making a solo escape stick all the way to the finish, but it would have been worth a try, given the prize.

The Tour is riddled with traditions and protocols, many of them to be cherished. The daftest, however, is the convention that no one attacks on the run to Paris – at least until the sprinters, a breed apart, unleash their death-or-glory stampede.

Protection of the yellow jersey is the idea, but it makes little sense. The Tour was last decided on the final day in 1989, when Greg LeMond snatched the maillot jaune from Laurent Fignon by eight seconds – the smallest margin in the race’s history – after a time trial. People are still talking about it.

The thousands of people gathering for the concluding stage, and the many millions who watch the drama develop on television over three weeks, deserve the chance of that kind of climax, rather than the certainty of its denial.

After 10km today Contador and Schleck broke away for a replay of Thursday’s duel on the Col du Tourmalet, but it was only a bit of larking about. After a couple of hundred metres there was a handshake for the cameras and a return to the somnolent pace of the peloton, whose members were able to resume another tradition, that of riding up to the front, one after another, to pay their respects to the yellow jersey.

The talent of the 27-year-old Contador and his three Tour victories make him worthy of their tributes, even though today he became one of only six men since the second world war to win the race without taking a stage victory en route. The others were Roger Walkowiak (1956), Gastone Nencini (1960), Lucien Aimar (1966), LeMond (1990) and Oscar Perreiro, who inherited the win in 2006 after the post-race disqualification of Floyd Landis.

There is no disgrace in joining that company but maybe it would have been better had Contador ridden away from Schleck on the Tourmalet. His decision to let his rival lead over the line seemed more than anything like a compensatory gift for his controversial attack on the Port Balès, where he took 39 seconds – a fateful figure, as it transpired – out of his rival while Schleck was trying to put his chain back on. Contador later issued an apology for breaching the race’s unwritten code of chivalry.

The champion was not at his best this year, as he admitted, and he was perhaps lucky that some of his leading rivals – notably Cadel Evans, Ivan Basso, Carlos Sastre and Bradley Wiggins – had expended energy during the Giro d’Italia that might otherwise have been used to attack him. But the fact that his form was a few percentage points below his normal standard is bad news for Schleck. The winner of the best young rider award rode bravely without the guidance and protection of his older brother, Frank, who broke his shoulder in a fall on the race’s fourth day, but he must wonder if he is ever going to force Contador to crack on a major climb.

The only uncertainty surrounding Contador is the name on the jersey he will be wearing next year. Astana, with the resources of the government of Kazakhstan behind them, are hoping to retain his services. Bjarne Riis, who is losing his Saxo Bank sponsorship, would like him to lead his next team. The dire state of the Spanish economy seems to have dimmed the prospect of Fernando Alonso, the Formula One driver and noted bike enthusiast, starting a team for Contador with backing from Santander. Whatever the outcome, the odds must be on a fourth Tour win next year.

Elsewhere today, the old protocols did withstand one frontal challenge. On Lance Armstrong’s last day as a Tour de France rider, the American’s obsession with his own interests brought the race close to farce. As the riders left Longjumeau, the commissaires noticed that he and the other eight members of his RadioShack team were wearing black jerseys emblazoned with the yellow logo of Livestrong, the organisation that covers both Armstrong’s cancer foundation and, increasingly, his own commercial activities. A change of colours is against the Tour’s rules, and they were forced to stop, replace the jerseys with their regular red shirts, and reaffix their race numbers, held on with safety pins, before being allowed to continue on their way to collect the team prize. “The idea was to talk about the significance and magnitude of the fight against the disease,” Armstrong said, “but the commissaires didn’t see it that way. In the end I suppose what happened probably brought more attention.”

Later, in a gesture of apparent defiance, all nine riders put the black jerseys back on for the podium ceremony. Armstrong may not have won his final Tour de France, but he was always going to have the last word.

The best mobiles: which phone should you pick next?

iphone,blackberry

The mobile phone has had more impact on daily life than any other object of the past decade. It’s changed how and where most Britons communicate, spawned a global industry in hardware and software – and because it’s killed the phone box, it’s even changed our landscapes, too.

Changes in mobile technology also mean that there’s never an excuse for not knowing your train was cancelled, that the idea of being out of email contact is increasingly implausible, and that taking pictures of any event, good or bad, is just a matter of grabbing your phone.

But while the possibilities are endless, the market is crowded. Touchscreens, pioneered by Apple and its iPhone, are rapidly starting to dominate the top of the market, but many users stick doggedly to handsets with physical keyboards. The global sales of “feature phones”, with traditional dialling keypads and more limited features, remain strong because they’re now so inexpensive.

As the market has begun to mature, too, there are now emerging trends for ultra-luxury mobile phones made by companies such as Vertu, with extraordinary standards of handmade craftsmanship genuinely akin to that of expensive watches. And fashion is playing an increasing role in the design of handsets as objects of aspiration.

If you’re setting out to buy or upgrade a mobile phone, however, there are three crucial questions to consider: what do you want to do with it, how much do you want to pay and which network do you want to be on?

The first question is simply not one that would have been asked a few years ago. iPhones and handsets made using Google’s Android operating system now let you listen to music, surf the web, check emails and watch films. Phone calls and text messages are old hat. The downside is fairly miserable battery life – 24 hours is unusual, by comparison with four or five days for a mid-market, basic handset. So a world of apps, movies and permanent connectivity is balanced by a need to charge everything more often.

Those apps, the small pieces of software you can download to augment the functions built in to a mobile phone, are also a growing and much-publicised part of mobile phones. Whether it is mobile gaming using Facebook or getting the cheapest deals on shopping, they can make enormous differences. eBay’s new app, for instance, allows you to scan any bar code and then see if it is available cheaper on the site’s global marketplace. Such technology unleashes new economic possibilities that simply did not exist until recently.

Price, too, is vital. One of the cheapest ways to get an iPhone 4 is on Tesco Mobile – but the total cost over a 12-month contract works out at £49 per month, once you’ve factored in the handset cost and the line rental. An HTC Desire on Vodafone will set you back just £35 per month, although it’s on an 18‑month contract and you might wish to upgrade the memory card if you’ve got a lot of music. The handsets are not identical, but they are comparable.

In many ways, which phone you buy now comes down to how much you want to pay for image. Judging by the fact that three-quarters of iPhone 4 orders were from people who owned iPhones already, loyalty and image are powerful forces when it comes to mobile phones.

These are devices many people now believe speak volumes about who they are as individuals, and they’re prepared to pay significant amounts of money.

Networks are also becoming a more important part of the jigsaw: as more phones use more data, the price that is charged to access the web and email is becoming more important. Even a generous 750mb of data per month, easily available for £20, would be wiped out, however, if a user starts to watch five minutes of video per day.

And while O2 scored a major PR victory by securing the iPhone exclusively, it found out the hard way that networks must build huge capacity for data use. Many iPhone users initially experienced significant frustrations. Vodafone and Three have subsequently sought to capitalise on their strength in data, and meanwhile, mobile network Giffgaff aims to sweep up a segment of the market that dislikes being associated with giant corporations, even though it is a wholly owned subsidiary of O2.

If there’s a conclusion, however, it’s a hopeful one: as phones become more like mini computers, they’re becoming more and more upgradeable. So among the best Android phones on the market is still the ageing Google Nexus One, because it carries the latest software.

Apple’s iPhone 3GS, too, upgrades to the iPhone 4 software and offers much of the same functionality. These two companies make the crucial elements to new phones: the interface.

So as we all use our phones to run aspects of our daily life, what matters more and more is the ability to keep pace. Only Google and Apple currently offer that.

iphone,blackberry

iphone,blackberry

Metro promises a banking revolution

metro bank

Nightclub lounge, cinema foyer or even amusement arcade are just some of the descriptions of the new branch of Metrobank opening this week in Holborn, central London.

Regardless of the looks or the marketing hyperbole, the opening of the first brand new bank on the British high street for more than 100 years is a red letter day for banking. Metro promises a new customer-focused experience, with longer opening hours, seven-days-a-week counter service, easy-to-use change machines and a fast-track current account opening procedure which could see new customers issued with a secure debit card within 15 minutes.

“We asked British consumers what they hate about their banks – from refusing to take change in large batches to constantly selling to them in the branch – and looked to do the complete opposite,” said Metro’s chairman, Anthony Thompson.

To back this up, Metro says that staff bonuses will be linked to levels of customer satisfaction rather than how many products are sold.

“The attitude of the big-name banks has been that the UK marketplace is mature and difficult to make money from unless they incentivise staff through commissions and targets for selling add-on products,” Mr Thompson said. “So you come in with a question about your current account and find that the staff member tries to sell you a credit card or a mortgage as a matter of course. Our staff are paid on how well they meet the customers’ needs, not on selling product.” Significantly, Mr Thompson has confirmed that although the Metro idea is imported from the US, customers will not have to pay US-style monthly fees on their current accounts.

It seems that Metro is targeting small businesses which often have to pay fees for everyday banking facilities such as depositing coins. “The location is interesting as there are lots of small businesses in the locality and the opening hours – till 8pm – and the ability to deposit coins in large quantities easily and without charge will really appeal to these customers,” said David Black, a banking analyst at Defaqto, a financial information firm. For dog-loving Britons, Metro says it will even allow pooches into branches and will be feeding them with dog biscuits.

Metro doesn’t want to stay rooted to one spot for long. It plans to open four branches by the end of this year and eight the next, all inside the M25, and within a decade have a 10 per cent share of the London banking market. Ambitious? It’s been done before in the United States by Vernon Hill, co-founder of Metro, who started with one branch in New Jersey in 1973 and grew Commerce Bancorp to 500 branches by 2007, with £50bn of assets, making it, at the time, the 17th biggest bank in the US. The template was similar to that being envisaged for the UK: attract new customers, usually angered at the service offered by the big boys, with promises of greater convenience and transparency.

But the UK market, which Metro is trying to crack, is more homogenous than the US, with a handful of massive players such as Lloyds Banking Group, Barclays, NatWest, HSBC and increasingly Santander forming a big five grabbing all but a small fraction of customer current accounts – the hub around which other products are sold. The big five enjoy huge economies of scale and are able to offer rates which can attract new customers as well as the advantage of substantial nationwide branch networks. In short, Metro and other potential new entrants have a huge job ahead of them. “It’s a tough task to grab even a proportion of the London market,” Mr Black said. “You need either to have a brand that people recognise and trust or you have to top the best-buy tables in order to really make strides in this country.” But Mr Black added that the “niche” approach of Metro is certainly interesting, tapping as it does into an anti-bank zeitgeist much the same way as First Direct managed to do 20 years ago.

However, when it comes to rates paid on savings and current accounts, Mr Thompson admitted that it will not be the best buy. “We aim to be a consistently high-rate payer rather than offering a headline-grabbing rate that is here today, gone tomorrow.”

Metro isn’t the only likely new entrant into the British banking market. Aldermore, previously a private bank, moved into the high street arena last year and currently offers best buys in the fixed-rate savings market as well as lending £300m to small- and medium-size businesses. Lord Levene, the chairman of Lloyd’s of London, and David Walker from Morgan Stanley said last month that they were trying to raise hundreds of millions from the City to launch Project New Bank based, you guessed it, around supplying better levels of customer service and empowering managers in branches to make lending decisions, as mainstream banks did in the UK until the early 1990s.

Both Tesco and Virgin have said that they want to enter the market and they have, in Tesco’s case, brand strength and branch coverage, and in Virgin’s case huge brand loyalty. “The barriers to entry are enormous in the UK and it’s a difficult task to break through and we have a trusted brand,” Virgin spokesman Scott Mowbray said. Virgin won’t be entering the market until 2011 at the earliest. The reason? “We have to ensure that we give customers the economic imperative to open a current account – which is key, as that’s the lifeblood of your business. At present, only 6 per cent of people switch their accounts a year,” Mr Mowbray said.

Virgin and Tesco, which has long-standing experience in supplying insurance products and the advantage of its Clubcard scheme for building brand loyalty, will be watching Metrobank’s launch closely. “It’s a really interesting development and no one has seen anything yet like Metrobank on the British high street,” said Mr Mowbray. “Much of what they are saying we agree with. For example, there has been for far too long in bank branches a sales culture rather than a professional customer service culture. People want simplicity and ease of access. That’s what the new entrants into the market should be looking to supply.”

And as customer satisfaction with banks is at an all-time low – particularly after the pitched battle over unfair overdraft fees – the will may be there for something completely different.
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Dollar steady as European crisis worries ebb

NEW YORK — The dollar was little changed Friday against major currencies after European Union leaders moved to calm fears of a financial crisis.

The dollar lost ground against currencies in emerging markets as stock markets moved higher, increasing traders’ desire to make riskier bets.

In late trading in New York, the euro slipped to $1.2364 from $1.2379 late Thursday. In overnight trading, it hit a high of $1.2416, its strongest level since late May.

The euro has risen from a four-year low below $1.19 on June 7 after positive economic data from around the world. European leaders’ moves to calm investors, who are worried that increasing public debt will trigger a banking crisis, is also helping bolster the currency.

On Thursday, EU leaders meeting in Brussels said they would publish results of “stress tests” of Europe’s 25 biggest banks in July. The measure will test banks’ financial stability.

“We think this move will promote transparency, allow financially sound banks to seek market refinancing and ultimately instill confidence in European financials,” said Credit Suisse foreign exchange analysts in a research note Friday.

Concern that Spain could follow Greece in requiring financial aid also receded somewhat Friday after a successful bond auction and support from EU leaders.

The real estate market collapse and rising unemployment have left Spain’s regional banking system struggling.

French President Nicolas Sarkozy, noting that he was speaking on behalf of the 27-nation group, said “we don’t believe there is a problem” in Spain.

The threat of a financial crisis spreading across Europe prompted the European Union and International Monetary Fund to put together an emergency financing package in May of more than $900 billion for euro countries.

Spain is a much bigger economy than Greece. A crisis there could have even deeper repercussions for the world economy.

While the euro has been slowly rising this week, analysts question the sustainability of the rally.

“We are still fundamentally bearish on the euro,” said UBS analyst Geoffrey Yu.

In other trading in New York, the British pound dipped to $1.4799 from 1.4810, while the dollar slipped to 90.73 Japanese yen from 90.82 yen.

The dollar edged down to 1.0222 Canadian dollars from 1.0284 Canadian dollars, and fell to 1.1098 Swiss francs from 1.1126 francs. It also lost some ground versus currencies in emerging markets in Latin American and Asia, as well as “commodity currencies” such as the Australian dollar.

Currencies of countries that are big commodity exporters tend to trade higher when investors are reassured by better than expected economic news or developments. A rebounding economy would require more commodity exports.

Ref Coulibaly could face FIFA probe

Malian referee Koman Coulibaly, the subject of vicious attacks in the US media after disallowing a late goal by USA in their 2-2 draw with Slovenia, could be asked to face FIFA’s refereeing committee to explain his decision.

Maurice Edu fires into the net but his goal is disallowed

A FIFA source told a US newspaper that Coulibaly could be asked to clarify the reasons for his disallowing the 86th-minute Maurice Edu goal even though there was general confusion for the reasons behind his decision.

USA forward Landon Donovan said: “We asked the ref many times what it was or who it was on and he wouldn’t or couldn’t explain it. I don’t know what to think of the call because I didn’t see any foul, just a normal free kick and a goal.”

Referees must submit a written report to FIFA after each match, but there is no requirement to explain every decision. FIFA rules state: “On the report form the referee shall note all occurrences such as misconduct of players leading to caution or expulsion, unsporting behaviour by supporters and/or by officials or any other person acting on behalf of an association at the match and any other incident happening before, during and after the match in as much detail as possible.”

After the group stage, FIFA assess the performances of all officials and decide which ones to retain for the knockout stage of the tournament.

“If [Coulibaly] is found to have made a serious mistake, especially one that affected the outcome, then he would be highly unlikely to play any further part in the tournament,” an unnamed source said. “FIFA is determined to keep refereeing standards high and does not want high-profile mistakes.”

Coulibaly, 39, is one of Africa’s most experienced referees and has been officiating for 17 years . Earlier this year he refereed the final of the African Cup of Nations between Ghana and Egypt.

Drug for Sexual Desire Disorder Opposed by Panel

tkatef com

tkatef com


A federal advisory panel on Friday unanimously voted against recommending approving a drug to treat female sexual desire disorder, but it encouraged the company to continue its research.

That vote by the panel, an adviser to the Food and Drug Administration, followed an F.D.A. staff report earlier this week that also recommended against approval. Such advisory votes do not always influence the F.D.A.’s final decision on a drug, but often they do.

The panel, the Reproductive Health Drugs Advisory Committee, voted against a new drug application by Boehringer Ingelheim, a German pharmaceutical company. Dr. Julia V. Johnson, the panel’s chairwoman, said that the drug’s impact was “not robust enough to justify the risks,” which include dizziness, nausea and fatigue, particularly with long-term daily use.

But Dr. Johnson, head of the department of obstetrics and gynecology at the University of Massachusetts Medical School, encouraged Boehringer to perform more research. The drug, originally intended as an antidepressant, was meant to elevate sexual desire in premenopausal women who are distressed by diminished libidos.

Another panel member, Dr. Kathleen Hoeger, a reproductive endocrinologist with the University of Rochester Medical Center, said that the research was “incredibly important” but that more work was required to improve long-term safety.

The Boehringer drug, flibanserin, affects brain chemicals, like dopamine and serotonin, thought to be involved with sexual drive.

The F.D.A. staff found that it had effectively increased the number of sexually satisfying events reported by more than 1,000 women with depressed libido, increasing those events by a statistically significant 0.8 per month in randomized, placebo-controlled experiments.

But the staff found the drug had not been proved to increase women’s desire — a crucial element of the diagnosis, which involves low or no sexual interest to the point of distress in otherwise healthy people.

The diagnosis, called hypoactive sexual desire disorder, is itself controversial. In the last month Boehringer has mounted a publicity campaign promoting the disorder, in advance of F.D.A. decision-making.

Dr. Anita H. Clayton, a Boehringer consultant and psychiatry professor at the University of Virginia, said the desire disorder affected 6 to 10 percent of premenopausal women, although that estimate was challenged by several speakers at the advisory committee hearing.

Boehringer will continue its research on the drug, a company official said after the vote.

“We are disappointed with the advisory committee’s recommendations and will work with the F.D.A. to address questions raised,” Dr. Christopher Corsico, Boehringer’s United States medical director, said in a statement.

Earlier this week, the company said it was also working in other countries to gain approval for the drug. Lara Crissey, a spokeswoman, wrote in an e-mail message, “We are in discussions with various regulatory agencies worldwide.”

The panel’s 11-to-0 vote was the second time in six years that an F.D.A. advisory panel had unanimously opposed a drug maker’s attempt to treat the female sexual dysfunction. There is no approved drug for the condition.

Various hormonal therapies have been tried.

The F.D.A. rejected a proposed testosterone patch from Procter & Gamble in 2004. That product was approved in Europe in 2006 for use by women who suffered low libido after removal of their uterus and ovaries, after all other forms of sex therapy failed. The product, Intrinsa, has been widely used by women in England who are not surgically menopausal.

BioSante Pharmaceuticals of Illinois plans to seek F.D.A. approval next year for a testosterone product called LibiGel, its spokesman, Alan Zachary, said Friday.

Some doctors already prescribe hormone therapies in so-called off-label uses. Over 4 million testosterone prescriptions were written for women’s sexual dysfunctions in 2009, although it has not been approved by the F.D.A. for that, said Stephen M. Simes, BioSante’s president.

Sheryl A. Kingsberg, a psychologist, Case Western Reserve University medical professor and prominent industry consultant, said widespread off-label use of hormonal drugs indicated a pent-up demand for pharmaceutical help for women.

Professor Kingsberg said Friday that she was disappointed in the F.D.A. advisory vote because Boehringer’s product would have been the first one on the market for younger women with the sexual desire disorder, treating them without hormones.

“I certainly hope Boehringer doesn’t give up,” she said in a phone interview. “Flibanserin showed an awful lot of promise. I’m going to have some very, very disappointed patients if there’s nothing for them.”

But Amy Allina, program director for the National Women’s Health Network, an advocacy group, said: “For some it may turn out that there is a drug that provides effective treatment. But this drug is not it.”

Artest’s Buzzer-Beater Douses the Suns’ Rally

LOS ANGELES — Kobe Bryant had Ron Artest wrapped in a bear hug, which was then engulfed by a group hug, all while shiny purple and gold streamers poured from the sky. Bryant was beaming, jovial at last.

To that emotion, he could have added surprised, elated and maybe even relieved.

As a tie game dwindled to its final seconds Thursday night, Bryant shot an air ball and Artest turned it into a buzzer-beating, game-winning and possibly series-turning layup. The Los Angeles Lakers danced away with a 103-101 victory over the Phoenix Suns, and a 3-2 lead in the Western Conference finals.

“As a group, it’s always fun to have wins like this,” Bryant said, his mood substantially improved from earlier in the week.

The Lakers are one victory away from a third straight trip to the N.B.A. finals and a chance to defend their title. Game 6 is Saturday in Phoenix. It is unlikely the series can get any wilder or weirder than it was Thursday night.

Suns Coach Alvin Gentry, struck by food poisoning, vomited in the first half and needed intravenous fluids at halftime. The Lakers blew an 18-point lead in the second half. The Suns nearly forced overtime on a bank-shot 3-pointer by Jason Richardson with 3.5 seconds left.

Then Artest, who might have left as the most vilified player in the building, became the Lakers’ unlikely savior.

With the score tied at 101-101, Bryant took an inbounds pass on the sideline, then turned and flung a 3-point attempt. Artest charged into the paint, caught the ball and quickly laid it back up as time expired, setting off a spectacular celebration at Staples Center.

Bryant finished with 30 points, 11 rebounds and 9 assists — a total that did not include his unintentional feed of Artest on the game’s final play.

Artest, who joined the Lakers last summer to provide toughness and defense, was asked if it was the biggest shot of his career.

“Biggest layup,” he said with a smile. “I missed a lot of layups during the regular season.”

Fans have found Artest alternately thrilling and maddening, and he was both Thursday night. His decision making and shooting have been heavily critiqued.

With about a minute to play, and the Lakers clinging to a 101-98 lead, Artest shot an errant a 20-foot jumper, the crowd groaning before he even released it. Pau Gasol grabbed the rebound and passed back to Artest at the 3-point arc. Seeing an open shot, Artest launched and missed again, to more groans.

In the timeout that followed, Coach Phil Jackson tried to give Artest — who was 1 for 8 at that point — a quick primer on good shots versus bad shots.

“He was trying not to listen to me, very hard,” Jackson said with a grin.

Yet Jackson sent Artest back onto the floor for the final 51.5 seconds.

“I actually questioned it myself when I put him out there on the floor,” he said.

It turned out to be a good decision. As Jackson noted, “He has an uncanny knack of doing things.”

The Suns, who did not hold a lead in the second half, nearly orchestrated their own miracle, after their own series of misfires. Channing Frye, Steve Nash and Jason Richardson all missed potential tying 3-pointers. But Richardson got another chance, and banked in a shot from 27 feet with 3.5 seconds left.

For a moment, the Suns were the ones hooting and skipping across the court.

“It was a crazy game,” said Nash, who led the Suns with 29 points and 11 assists, including 9 points in the fourth quarter.

Two nights earlier in Phoenix, the Suns had tied the series and sent Bryant into a foul mood. Asked to describe his emotions afterward, Bryant had said, sarcastically, “Jovial.” This time the feeling was genuine.

Derek Fisher had 22 points, his most productive game of the postseason. Gasol started to reassert himself in the paint, finishing with 21 points and 9 rebounds. Lamar Odom contributed 17 points and 13 rebounds. Bryant and Andrew Bynum had four blocks apiece.

The trends now favor the Lakers. In the history of 2-2 ties, the team that wins Game 5 has gone on to win the series 83 percent of the time.

Nash frustrated the Lakers defense all night with his slippery moves and smooth shooting. He was at his best down the stretch, scoring on a 3-point play, feeding Amare Stoudemire for a layup and hitting two long jumpers over Gasol.

Phoenix again used heavy doses of zone defense, holding the Lakers to a series-low 41.8 percent shooting. The Suns’ bench, a key to their victories in Games 3 and 4, was not nearly as effective on the road. Frye scored 14 points, all in the second half, and Jared Dudley had 10 points. No other reserve had more than 3. Dudley was the only Suns reserve to score in the first 30 minutes of play.

On the Suns bench, they were just hoping to keep their coach upright. Gentry became ill early in the game and vomited in a trash can by the bench. It was not intended as a symbolic gesture.

“I ate at a restaurant today that will not be named,” Gentry said. “But for some reason it did not sit well with me.”

Gentry felt better by the end of the game, and then not so much.

“We’re not happy, I can tell you that,” he said. “We’re very disappointed. We’re not jovial.”

Shell Agrees to Buy Natural-Gas Exploration Company

Royal Dutch Shell PLC said Friday it has agreed to buy East Resources Inc., a closely held U.S. natural-gas explorer, for $4.7 billion, in a transaction that underscores the frenzied global interest in North American shale-gas production.

Warrendale, Pa.-based East Resources is one of the biggest players in a natural-gas exploration area known as the Marcellus Shale, with control of 1.25 million acres across a territory that stretches from West Virginia to New York.

The sale will provide lavish returns for private-equity firm Kohlberg Kravis Roberts & Co., which invested $350 million in East Resources for a substantial stake only 11 months ago. It will also be a boon for East Resources Chief Executive Terrence Pegula, who founded the company in 1983, and still controls it.

Shell’s acquisition also includes mineral rights in the Eagle Ford Shale in south Texas.

While natural gas prices remain depressed, major oil companies are moving deeper into the business, with expectations that gas demand will recover in the years ahead. Last December Exxon Mobil Corp. agreed to buy gas producer XTO Energy Inc. for about $30 billion.

No area is more in demand than the Marcellus, a natural-gas field stretching from West Virginia to New York. It has benefited from big production and relatively low costs, which have made wells profitable and increasingly valuable.

North American natural gas currently accounts for about 7.8% of Shell’s global oil and gas production. Shell has pursued several deals in the North American gas market in recent years, buying Canada’s Duvernay Oil Corp. in 2008, and teaming up with Encana Corp. to develop acreage in Louisiana’s Haynesville Shale exploration area. Shell officials have said they believe that while gas prices are low now, in the long-term they will recover.

Foreign energy companies have moved aggressively on to the scene. Last month, India’s Reliance Industries Ltd. invested $1.7 billion for a 40% stake in a joint venture with Atlas Energy Inc., which controls about 584,000 acres in the Marcellus. In February, Japan’s Mitsui & Co. announced a deal with Anadarko Petroleum Corp. in which it will invest about $1.4 billion to develop shale gas in the region.

The shale investments come with regulatory risks. Environmental groups and some residents of gas-producing areas have become concerned that the drilling process used to extract natural gas trapped in shale formations uses too much water and could contaminate water supplies, a concern that is particularly acute in Pennsylvania and New York. A U.S. House committee is investigation the process, known as hydraulic fracturing,or “fracking,” and some lawmakers have called for increased regulation.

The natural-gas industry insists fracturing is safe and that generating electricity from natural gas uses less water than other power-plant fuel sources.

For KKR, the deal represents a big win as the New York investment firm nears a listing on the New York Stock Exchange. A deal would allow KKR to return money to investors in its flagship $17.6 billion fund as it sets its sights on raising new funds. Separately, Toys “R” Us Inc., the retailer owned by KKR, is expected to file for an initial public offering late Thursday.

Israel’s Gaza blockade baffles residents

GAZA CITY, Gaza Strip — Military bureaucrats enforcing Israel’s blockade of Gaza allow frozen salmon filet, facial scrub and low-fat yogurt into the Hamas-ruled territory. Cilantro and instant coffee are another matter — they are banned as luxury items.

Over the past three years, Israel has determined down to the tiniest detail what gets into the Gaza Strip and to its population of 1.5 million, using secret guidelines to differentiate between humanitarian necessities and nonessential luxuries in its blockade meant to squeeze the Islamic militant group Hamas.

The results are often baffling.

“Frozen salmon — we never had it before the blockade,” said perplexed salesman Abed Nasser, examining a frozen chunk of fish.

Critics have long maintained that Israel’s blockade, imposed after Hamas’ violent takeover of Gaza in 2007, has not just been confusing, but counterproductive. It has come under renewed scrutiny this week as hundreds of pro-Palestinian activists sail a flotilla to Gaza loaded with thousands of tons of goods.

Israeli Col. Moshe Levy, a senior military official dealing with Gaza, called the flotilla a “provocation” and said all necessary humanitarian aid already reaches Gaza. Israeli officials say they will stop the flotilla by hauling the ships to an Israeli port if they don’t turn back.

Critics say the blockade has failed to dislodge Hamas and has hurt Gaza’s poor and blocked reconstruction after Israel’s devastating three-week military offensive in the winter of 2008-2009. A Palestinian industry report says the blockade has wiped out over 100,000 jobs in Gaza by banning raw materials and stifling trade.

With small exceptions for international aid projects, raw goods vital for trade and construction are banned. A biscuit factory cannot import margarine, and a tomato paste factory cannot bring in empty cans. While fruits, vegetables and frozen meats are let in, fresh meat, vinegar and jam, are not, said Sari Bashi of the Israeli rights group Gisha.

“There are enough quantities of basic food items in Gaza. But because there is a ban on raw materials needed for production and a ban on exporting finished products, people don’t have enough money to buy things,” she said. “That’s why 80 percent of Gaza residents are dependent on international assistance.”

Meanwhile, tunnels built under the Gaza-Egypt border haul in scarce goods at inflated prices, enriching smugglers and Hamas, which taxes the trade. Gaza markets are filled with smuggled products like chocolate sauce and shiny children’s shoes that most residents cannot afford.

Hamas officials have used smuggled cement to rebuild the notorious Ansar prison where they detain their rivals, and are currently building a shopping center.

But three years after the blockade, Israel is only now shipping in the building materials the U.N. needs to construct 151 apartments for some of Gaza’s poorest residents.

“Gaza is being reconstructed — it’s just that the U.N. is not doing any of the reconstruction,” said U.N. spokesman Chris Gunness. He said the U.N. still had not been given permission to build another 450 apartments in the same project, nor to start rebuilding the 2,400 homes that were destroyed during the war.

Israel has bristled at criticism, insisting there are no shortages of food or other essential goods. On Wednesday, Israel’s Government Press Office issued a news release sarcastically encouraging people to visit one of Gaza’s few upscale restaurants, Roots Club, which uses a mixture of smuggled and legally imported goods for its menu.

“We have been told the beef stroganoff and cream of spinach soup are highly recommended,” it said, attaching a menu.

The press office’s director, Daniel Seaman, said he issued the release to counter “propaganda” about a humanitarian crisis in Gaza.

Gaza’s tiny elite and foreigners are well served by the handful of restaurants like Roots, where a meal costs more than a typical Gazan’s daily wage. But such places are out of reach for virtually all of Gaza’s residents, who overwhelmingly rely on U.N.-donated food aid.

Israel says the blockade aims to dry up Hamas’ homegrown weapons industry by keeping out steel that can be forged into rockets and fertilizer that can be turned into explosives.

Officials say the blockade also constrains Hamas’ ability to rule and pressures it to release Sgt. Gilad Schalit, an Israeli soldier held captive for four years.

With Egypt destroying some tunnels and restricting the inflow of cash, Hamas has struggled to pay the salaries of its 32,000 civil servants and security forces in recent months. But Hamas remains firmly in power, and residents are left uncertain about what Israel will allow in at any given time.

Israeli refuses to say what it bans or permits. The government said revealing that information would harm Israel’s security and foreign relations, in response to a court challenge by the rights group Gisha in May.

Maj. Guy Inbar, an Israeli military official, said Israel bans “luxury” food items because they “will not be consumed by the public — but only by the rich and corrupt Hamas leaders.”

The luxuries include goods considered staples in Gaza, like honey, instant coffee and spices, according to Bashi and Palestinian liaison official Raed Fattouh.

Not included are the frozen seafood or low-fat yogurt purchased by Gaza’s wealthy few at the al-Rimal supermarket, or facial scrubs and skin-whitening sunscreen at a nearby upmarket pharmacy — all from Israel. Seafood comes as frozen meat, skin creams as feminine hygiene products and diet yogurt comes as dairy, categories permitted by Israel.

Some items have now been allowed to enter after being banned for years, like clothing, shoes and tea, providing the surreal sight of gleaming, expensive boxes of Israeli-imported caffeine-free blueberry tea sold alongside knocked-around boxes of tunnel-smuggled black tea.

“Sometimes we ask (the Israelis) why some things are banned,” Fattouh said. “‘Release Schalit and make Hamas step down and then we’ll lift the blockade,’” he said, quoting Israeli officials. “But there’s no problem if you want to have a salmon dinner.”